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KMID : 0376219650020010033
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Chonnam Medical Journal
1965 Volume.2 No. 1 p.33 ~ p.37
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Experimental Studies on the Recovery Rate of Phagocytic Activity of Retivuloendothelial System after Blockade
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Abstract
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The recovery rate of phagocytic activity of the reticuldendothetial system (RES) in rabbits was investigated with radioactive blocking agent, collargol-I^(131), which was injected intravenously after the non-radioactive collargol had been given for six days in order to block the RES.
1. The results indicate that even a large amount of the blocking agent could not lead to complete dearrangement in the phagocytic activity.
2. There could be found organ-differences in the degree of responses to the blocking agent. Thus, the degree of blockade in the phagocytic activity was most marked in the bone marrow, and slight in the liver. In contrast, in the spleen and adrenal glands an increase of the phagocytic activity was found.
3. The time required to recover to normal from the states of dearrangement was ranged between 6 and 20 days after the blockade, but there could be found organ differences in the degree of recovery rate; 6 to 12 days in the liver and 20 days in the bone marrow was required. In the spleen the recovery to normal level from an increased activity required 20 days. An exception in this aspect was found in the adrenal glands, which showed a continuing increase in the phagocytic activity after the blockade.
4. The disappearance of the collargol-I^(131) from the blood did not differgreatly at any recovering time after the blockade. The renal uptake of collargol-ll31, however, was decreased as the recovery in the phagocytic activity of the RES was proceeding.
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